Saturday, December 16, 2017

On B6, Peripheral Levodopa, Carbidopa, AADC

Collecting references here - add more in the comments if you find them:
http://jnnp.bmj.com/content/34/6/682
Full text
http://jnnp.bmj.com/content/jnnp/34/6/682.full.pd



EFFECT OF PYRIDOXAL PHOSPHATE DEFICIENCY ON


AROMATIC L-AMINO ACID DECARBOXYLASE ACTIVITY


WITH L-DOPA AND L-5-HYDROXYTRYPTOPHAN

AS SUBSTRATES IN RATS

Mohammed Khalilur RAHMAN*, Toshiharu NAGATSU**, Tae SAKURAI***,

Seiji HORI***, Miyako ABE*** and Makoto MATSUDA***

Laboratoryo f Cell Physiology,D epartmento f LifeC hemistry,

Graduate School at Nagatsuta, Tokyo Institute of Technology, Yokohama 227, Japan

Accepted May 10, 1982
 

https://pdfs.semanticscholar.org/b602/24d0da62d2dff4a48e39dcbf9e14318c17ce.pdf


On the mechanism of the nullification of CNS effects of L-DOPA by pyridoxine in Parkinsonian patients
Article · October 1972with5 Reads
DOI: 10.1111/j.1471-4159.1972.tb05126.x · Source: PubMed
https://www.researchgate.net/publication/18097207_On_the_mechanism_of_the_nullification_of_CNS_effects_of_L-DOPA_by_pyridoxine_in_Parkinsonian_patients


Drugs
, Volume 11, Issue 5, pp 329–377 | Cite as

Levodopa and Decarboxylase Inhibitors: A Review of their Clinical Pharmacology and Use in the Treatment of Parkinsonism


December 27, 1971

Pyridoxine Antagonism of Levodopa in Parkinsonism

Author Affiliations

From the Department of Medical Pharmacology, Hoffman-La Roche, Inc, Nutley, NJ, and the Special Treatment Unit, Newark (NJ) Beth Israel Medical Center. Dr. Abrams is now with Ayerst Laboratories, New York.

JAMA. 1971;218(13):1924-1927. doi:10.1001/jama.1971.03190260040011
Need Full Text


Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase.


Burkhard P, et al. Nat Struct Biol. 2001.
https://www.ncbi.nlm.nih.gov/m/pubmed/11685243/

Identification by Virtual Screening and In Vitro Testing of Human DOPA Decarboxylase Inhibitors

Frederick Daidone, Riccardo Montioli, [...], and Carla Borri Voltattorni
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285636/



Effect of pyridoxine on the depletion of tissue pyridoxal phosphate by carbidopa

Luisa Airoldi
Carol J. Watkins
Jane F. Wiggins
1
Laboratory of Neuroendocrine Regulation, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Mass.U

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