How might the condition of your sinuses correlate to Parkinson’s Disease?
If you have Parkinson’s, please take a quick (like 30 seconds) survey:
https://www.surveymonkey.com/r/YNLKHBN
Tuesday, September 11, 2018
Sunday, August 19, 2018
Over 5-1/2 Years of Powerful Food, Exercise, and Sunshine Success Against Parkinson's!
At the age of 38, in about 2007 - 2008, I began experiencing Parkinson's symptoms. I began taking levodopa drugs a year or two later. In 2011, I was formally diagnosed by a team of prominent motion disorders specialists. Since then I have been re-diagnosed by 6 more doctors and a Parkinson's sniffing dog!
That set me on course for massive doses of drugs.
By 2013, I was being prescribed a medication escalation to over 2000 mg/day levodopa, Comtan, Azilect, anti-depressants, propranolol, and other drugs. These were at that time not controlling my condition well and when I was off medication such as during illness, I couldn't even walk. The tremors in my arms and leg were severe.
Surgery was suggested.
I had seen very mixed results with that, and I respected the gravity of brain surgery. So I placed DBS and/or other surgical interventions in the last resort spot.
Then in February of 2013, I began what has now been a 5-1/2 year journey of epiphanies contributing to recovery.
In August of 2014 I released my book "Powerful Food And A Walk In The Sun", detailing my journey to a drug-free, surgery-free vitality regained. Since then there have been many more successes and many new challenges.
A few examples:
Challenge - Twice in the last 5-1/2 years, motorists, both of them unprovoked complete strangers have deliberately hit my vehicle (one deliberately ran a red light, dodged oncoming traffic, and slammed into my car, another put his car into reverse and slammed into me as I was stopped several car lengths behind him at a light) Both times my neck was injured. These encounters escalated my Parkinson's symptoms.
Success - Three years ago I started Rock Stock Steady Boxing in addition to my walking. Every bit of added exercise and the connections with new friends have been essential.
Challenge - In 2016 I developed vitamin D poisoning, which caused elevated symptoms of Parkinson's, and many other symptoms.
Success - My more recent discoveries such as magnesium, choline, lactic acid, probiotics, red meat elimination, treatment for SIBO, and dairy elimination have lead to significant recovery.
And the list just goes on.
I'm considering another book.
And I think the message is: Don't ever let them make you think your life is over! Keep your calm wits about you, use your head, it's NOT dead.
So anyway on this 5-1/2 year anniversary of my Powerful Food And A Walk In The Sun Journey, I am looking and feeling great, still on less than 30% of the medication prescribed almost 6 years ago, still have been able to avoid surgery, and still here to help all of you suffering from Parkinson's Disease!
Click the cover for a link to my book on Amazon.
Friend me on Facebook at: https://www.facebook.com/profile.php?id=100005011636168
Find me hanging out in the group Parkinson's Disease Fighters United at: https://www.facebook.com/groups/pd.fighters.united/
or email me, or whatever.
God Bless all of you! We're getting close to ending Parkinson's.
Glen
That set me on course for massive doses of drugs.
By 2013, I was being prescribed a medication escalation to over 2000 mg/day levodopa, Comtan, Azilect, anti-depressants, propranolol, and other drugs. These were at that time not controlling my condition well and when I was off medication such as during illness, I couldn't even walk. The tremors in my arms and leg were severe.
Surgery was suggested.
I had seen very mixed results with that, and I respected the gravity of brain surgery. So I placed DBS and/or other surgical interventions in the last resort spot.
Then in February of 2013, I began what has now been a 5-1/2 year journey of epiphanies contributing to recovery.
In August of 2014 I released my book "Powerful Food And A Walk In The Sun", detailing my journey to a drug-free, surgery-free vitality regained. Since then there have been many more successes and many new challenges.
A few examples:
Challenge - Twice in the last 5-1/2 years, motorists, both of them unprovoked complete strangers have deliberately hit my vehicle (one deliberately ran a red light, dodged oncoming traffic, and slammed into my car, another put his car into reverse and slammed into me as I was stopped several car lengths behind him at a light) Both times my neck was injured. These encounters escalated my Parkinson's symptoms.
Success - Three years ago I started Rock Stock Steady Boxing in addition to my walking. Every bit of added exercise and the connections with new friends have been essential.
Challenge - In 2016 I developed vitamin D poisoning, which caused elevated symptoms of Parkinson's, and many other symptoms.
Success - My more recent discoveries such as magnesium, choline, lactic acid, probiotics, red meat elimination, treatment for SIBO, and dairy elimination have lead to significant recovery.
And the list just goes on.
I'm considering another book.
And I think the message is: Don't ever let them make you think your life is over! Keep your calm wits about you, use your head, it's NOT dead.
So anyway on this 5-1/2 year anniversary of my Powerful Food And A Walk In The Sun Journey, I am looking and feeling great, still on less than 30% of the medication prescribed almost 6 years ago, still have been able to avoid surgery, and still here to help all of you suffering from Parkinson's Disease!
Click the cover for a link to my book on Amazon.
Friend me on Facebook at: https://www.facebook.com/profile.php?id=100005011636168
Find me hanging out in the group Parkinson's Disease Fighters United at: https://www.facebook.com/groups/pd.fighters.united/
or email me, or whatever.
God Bless all of you! We're getting close to ending Parkinson's.
Glen
Sunday, March 18, 2018
The Yeast Accident / Parkinson’s Epiphany
I’ve about done myself in whilst hydroponic gardening radishes with my daughter for her science project. 🤢
Late in the project we had fungus gnats develop in the enclosure.
But the plot thickens...After mixing it and applying it per the recommendations, I realize...
It’s 9.42% yeast!!!!
And I am allergic to yeast, and it’s a dread fungus!
So I think, “well I washed my hands in hot water” - but I started feeling weaker, shakier over the next few weeks while simultaneously going cold turkey on dairy. Then Friday I started smelling something like the substance itself in my sweat, breath - yuk! So I went to the doctor and got some diflucan, and it seems to be zapping it. My Parkinson’s meds are working significantly better! I should progressively get somewhat better over the next month... my IGG allergy to yeast takes a week or so to onset, then a month of inflammation. Here’s what the urgent care doc gave me:
Further you will note that during the horror I specifically had to escalate my carbidopa.... making me wonder if the yeast controls us by making vitamin B6 or AADC! Note also that the night I crashed off my dairy free bid, I recovered well from this yogurt:
http://www.whitemountainfoods.com/probiotics.html
So those lactobacillus and other strains appear to attack the yeast. But also remember they sold me that yeast based fungicide for organic cultivation... Makes me wonder if we’re getting loaded with yeast in organic fruits and vegetables.
Looked into this further, it turns out that yeast does in fact produce vitamin B6!
Candida Sythesizes B6
So beware - B6 converts your Levodopa into dopamine so it doesn’t enter your brain and stops your gut, and candida or yeast in your gut produces vitamin B6!
Further explanation added 3/18/8:
Two Cofactors, vitamin B6 and AADC control how much Levodopa from your mesenteric system, including your medication which enters through your mesenteric system, gets to your brain. B6 and AADC together convert levodopa to dopamine and dopamine does not appreciably cross the blood brain barrier (BBB): Higher levels of B6 and AADC prevent more levodopa from crossing the BBB; lower levels allow more levodopa to cross the BBB. 90% of the serotonin and 50% of the body’s Levodopa are produced in the mesenteric system so it’s reasonable to estimate that AADC is abundant, being required for both Serotonin and Levodopa. Therefore if organisms such as over abundant yeast are injecting B6 directly at the origin location of both mesenteric and medication levodopa, that levodopa is quickly converted to dopamine and kept from the brain. Further, other citations in the literature indicate that yeast grows faster in higher levels of B6, so levels of yeast keep rising and this process snowballs.
Late in the project we had fungus gnats develop in the enclosure.
So the folks at the hydro store recommended an “all natural” “organic” fungicide/ pesticide...
But the plot thickens...After mixing it and applying it per the recommendations, I realize...
It’s 9.42% yeast!!!!
And I am allergic to yeast, and it’s a dread fungus!
So I think, “well I washed my hands in hot water” - but I started feeling weaker, shakier over the next few weeks while simultaneously going cold turkey on dairy. Then Friday I started smelling something like the substance itself in my sweat, breath - yuk! So I went to the doctor and got some diflucan, and it seems to be zapping it. My Parkinson’s meds are working significantly better! I should progressively get somewhat better over the next month... my IGG allergy to yeast takes a week or so to onset, then a month of inflammation. Here’s what the urgent care doc gave me:
Further you will note that during the horror I specifically had to escalate my carbidopa.... making me wonder if the yeast controls us by making vitamin B6 or AADC! Note also that the night I crashed off my dairy free bid, I recovered well from this yogurt:
http://www.whitemountainfoods.com/probiotics.html
So those lactobacillus and other strains appear to attack the yeast. But also remember they sold me that yeast based fungicide for organic cultivation... Makes me wonder if we’re getting loaded with yeast in organic fruits and vegetables.
Looked into this further, it turns out that yeast does in fact produce vitamin B6!
Candida Sythesizes B6
So beware - B6 converts your Levodopa into dopamine so it doesn’t enter your brain and stops your gut, and candida or yeast in your gut produces vitamin B6!
Further explanation added 3/18/8:
Two Cofactors, vitamin B6 and AADC control how much Levodopa from your mesenteric system, including your medication which enters through your mesenteric system, gets to your brain. B6 and AADC together convert levodopa to dopamine and dopamine does not appreciably cross the blood brain barrier (BBB): Higher levels of B6 and AADC prevent more levodopa from crossing the BBB; lower levels allow more levodopa to cross the BBB. 90% of the serotonin and 50% of the body’s Levodopa are produced in the mesenteric system so it’s reasonable to estimate that AADC is abundant, being required for both Serotonin and Levodopa. Therefore if organisms such as over abundant yeast are injecting B6 directly at the origin location of both mesenteric and medication levodopa, that levodopa is quickly converted to dopamine and kept from the brain. Further, other citations in the literature indicate that yeast grows faster in higher levels of B6, so levels of yeast keep rising and this process snowballs.
Monday, February 5, 2018
Calculation Of Circulating Levodopa From The Mesenteric System, The Brain
Based on the paper “Substantial Production of Dopamine in the Human Gastrointestinal Tract “, 1997 by Eisenhofer et al , I wanted to see if I could develop a reasonable estimate for the amount of levodopa produced by the mesenteric system, and the amount of levodopa produced by the brain. The thinking is that we could put into perspective the contributions of your medicine, your gut, and your brain if your battling PD. So I used the information in the paper to perform calculations as follows:
How much Levodopa does the mesenteric system produce?
Levodopa molecular weight = 197.19g/MOL= 197.19 ng/nmol
Table 2,
States net mesenteric DOPA production as:
.65 nmol/min
197.19ng/nmol * .65 nmol/min = 128.17 ng/min, * 1mg/1E6ng = .128E-3 mg/min
Mesenteric Daily Production:
.128mg/min * 60min/hr *24hrs/day = 184.32 mg/day
Comparable to 2 Sinamet 100/25 per day.
Please note that this is conservative because all the individuals studied in the paper had either gut cancer, pancreatic illness, or heart disease.
The article states: “Up to 46% of the DA formed in the body ... is derived from the gastrointestinal tract, pancreas, and spleen.” Given that some of the remainder is produced in the peripheral nervous system, perhaps a generous estimate is that 50% is produced by the brain. So we have about another 2 Sinamet being produced in a healthy brain. Estimates widely cited have indicated that brain production is 50% compromised in the PD affected by brain at onset. So the brain is producing about 1 Sinemet at onset of symptoms for PWP.
In summary :
Mesenteric System (gut, pancreas, spleen) - produces about 2 Sinamet per day
Parkinson’s brain at onset - 1 Sinamet per day
So this seems to imply that if you’re taking more that 1 Sinamet per day as a PWP, you’re fighting another Dragon besides brain disease (something in your periphery is either failing to produce levodopa, overactively converting levodopa to dopamine, and/or overactively destroying levodopa) Possibilities include an overactive liver, overactive kidneys, and/or an unhealthy gut, unhealthy pancreas, improper vitamin B6 balance (and B6 is involved in 100
different processes), insufficient production of AADC enzyme and/or an unhealthy spleen.
Notice how very little levodopa is normally produced by your body. Depending on your stage of Parkinson’s and how much levodopa you’re taking, your medication dose can be 50x, 500x, or 5000x what the body normally produces. So it’s no wonder, results vary widely and side effects abound.
Find the article at:
https://academic.oup.com/jcem/article/82/11/3864/2866142
How much Levodopa does the mesenteric system produce?
Levodopa molecular weight = 197.19g/MOL= 197.19 ng/nmol
Table 2,
States net mesenteric DOPA production as:
.65 nmol/min
197.19ng/nmol * .65 nmol/min = 128.17 ng/min, * 1mg/1E6ng = .128E-3 mg/min
Mesenteric Daily Production:
.128mg/min * 60min/hr *24hrs/day = 184.32 mg/day
Comparable to 2 Sinamet 100/25 per day.
Please note that this is conservative because all the individuals studied in the paper had either gut cancer, pancreatic illness, or heart disease.
The article states: “Up to 46% of the DA formed in the body ... is derived from the gastrointestinal tract, pancreas, and spleen.” Given that some of the remainder is produced in the peripheral nervous system, perhaps a generous estimate is that 50% is produced by the brain. So we have about another 2 Sinamet being produced in a healthy brain. Estimates widely cited have indicated that brain production is 50% compromised in the PD affected by brain at onset. So the brain is producing about 1 Sinemet at onset of symptoms for PWP.
In summary :
Mesenteric System (gut, pancreas, spleen) - produces about 2 Sinamet per day
Parkinson’s brain at onset - 1 Sinamet per day
So this seems to imply that if you’re taking more that 1 Sinamet per day as a PWP, you’re fighting another Dragon besides brain disease (something in your periphery is either failing to produce levodopa, overactively converting levodopa to dopamine, and/or overactively destroying levodopa) Possibilities include an overactive liver, overactive kidneys, and/or an unhealthy gut, unhealthy pancreas, improper vitamin B6 balance (and B6 is involved in 100
different processes), insufficient production of AADC enzyme and/or an unhealthy spleen.
Notice how very little levodopa is normally produced by your body. Depending on your stage of Parkinson’s and how much levodopa you’re taking, your medication dose can be 50x, 500x, or 5000x what the body normally produces. So it’s no wonder, results vary widely and side effects abound.
Find the article at:
https://academic.oup.com/jcem/article/82/11/3864/2866142
Saturday, January 20, 2018
History and Background
Collecting reference papers here:
History of levodopa and dopamine agonists in Parkinson's disease treatment.
Wednesday, December 27, 2017
Friday, December 22, 2017
Eisenhofer et al on mesenteric dopamine
Substantial Production of Dopamine in the Human Gastrointestinal Tract
The Journal of Clinical Endocrinology & Metabolism, Volume 82, Issue 11, 1 November 1997, Pages 3864–3871, https://doi.org/10.1210/jcem.82.11.4339
Published:
01 November 1997
Article history
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